Endocrinology

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Immune changes in post-menopausal osteoporosis: The Immunos study
Osteoporosis International, 11/03/09

Breuil V et al. – These results suggest that, regardless of age and estrogen status, postmenopausal OP is associated with immune changes, highlighting a possible role of IFN-&Upsilon in the pathophysiology of OP and reporting, for the first time, changes in several B lymphocyte populations. These alterations may reflect the frailty observed after fracture, providing new insight into the mechanisms of morbidity and mortality associated with OP fractures.

• Analyzed surface markers of peripheral B, CD4+ and CD8+ lymphocytes and cytokine secretion in supernatants of these cells cultured with or without stimulation
• Body composition assessed by dual energy X-ray absorptiometry

• 2 groups were similar for age and estrogen level
• OP women had significantly lower BMI, fat mass, and lean mass
• Number of CD19+, CD19+/CD27+, CD19+/CD27+/CD5?/CD38+ and CD19+/CD27+/RANK+, CD4+/CD27+/CD45RA?/RANK+, and CD4+/CD27+/CD45RA?/CD28+ lower in OP women and positively correlated to BMD
• In OP women, under basal conditions, CD4+ secreted less IFN-? and B lymphocytes more granulocyte macrophage colony-stimulating factor (GM-CSF)
• GM-CSF positively correlated to fracture rate and negatively to BMD

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