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Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1- or PHOSPHO1-Deficient Matrix Vesicles
Journal of Bone and Mineral Research, 11/03/09

Ciancaglini P et al. – TNAP is the enzyme that hydrolyzes both ATP and PPi in the MV compartment. NPP1 does not have a major role in PPi–generation from ATP at the level of MVs, in contrast to its accepted role on the surface of the osteoblasts and chondrocytes, but rather acts as a phosphatase in the absence of TNAP.

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Jose Luis Millan, 11/03/09

Our paper has identified NPP1 as a backup matrix vesicles phosphatase, in the absence of TNAP. This finding helps explain why mice that are null for TNAP activity are still born with a calcified skeleton and only develop the rickets and osteomalacia characteristic of infantile hypophosphatasia at postnatal days 6-10.

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