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Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09

Rho YH et al. – TNF&alpha and IL-6 are significantly associated with the severity of subclinical atherosclerosis, independent of Framingham risk score, in RA.

Methods

Clinical variables, concentrations of inflammatory mediators, and coronary artery calcification measured in 169 patients with RA and 92 control subjects
Differences in concentrations of inflammatory mediators were compared using median quantile regression
Relationship of inflammatory mediators with severity of coronary calcification in RA and control subjects examined using proportional odds logistic regression, allowing for interaction with disease status
Models were adjusted for traditional cardiovascular risk factors

Results

Median serum concentrations of IL-6, SAA, ICAM-1, E-selectin, TNF&alpha , and MPO and peripheral blood neutrophil count were higher in patients with RA than controls , independent of Framingham risk score and diabetes mellitus (DM). IL-6 (main effect odds ratio [OR] 1.72; 95% confidence interval [95% CI] 1.12, 2.66) and TNF&alpha concentrations were significantly associated with higher amounts of coronary calcium, independent of Framingham risk score and DM, and such main effects significantly differed from controls

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Low protein C and incidence of ischemic stroke and coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study
Journal of Thrombosis and Haemostasis, 10/27/09 Relevance Score: 81%

Effects of Bariatric Surgery on Inflammatory, Functional and Structural Markers of Coronary Atherosclerosis
The American Journal of Cardiology, 10/21/09 Relevance Score: 81%

Relationship Between Baseline Coronary Calcium Score and Demonstration of Coronary Artery Stenoses During Follow-Up: MESA (Multi-Ethnic Study of Atherosclerosis)
JACC - Journal of the American College of Cardiology: Cardiovascular Imaging, 10/16/09 Relevance Score: 81%

Association of Electrocardiographic Abnormalities With Coronary Artery Calcium and Carotid Artery Intima–Media Thickness in Individuals Without Clinical Coronary Heart Disease (from the Multi-Ethnic Study of Atherosclerosis [MESA])
The American Journal of Cardiology, 10/15/09 Relevance Score: 81%

Association of inflammatory markers with angiographic severity and extent of coronary artery disease
Atherosclerosis, 10/08/09 Relevance Score: 81%