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Participants randomly assigned to make lifestyle changes also had more favorable cardiovascular risk factors, including lower blood pressure and triglyceride levels, despite taking fewer drugs to control their heart disease risk, according to the study. Researchers announced the initial findings of the DPP in 2001, a year earlier than scheduled because results were so clear: after three years, intensive lifestyle changes reduced the development of type 2 diabetes by 58 percent compared with placebo. Metformin (850 milligrams twice a day) reduced it by 31 percent compared with placebo.

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