Endocrinology Medical News about Pituitary ACTH Hypersecretion

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Medical treatment of Cushing's disease: Overview and recent findings
International Journal of General Medicine, 10/21/09

Praw SS et al. – Cushing's disease, due to pituitary adrenocorticotropic hormone (ACTH) hypersecretion, is the most common etiology of spontaneous excess cortisol production. The majority of pituitary tumors causing Cushing's disease measure <1 cm and the excess morbidity associated with these tumors is mostly due to the effects of elevated, nonsuppressible, ACTH levels leading to adrenal steroid hypersecretion. Elevated circulating cortisol levels lead to abnormal fat deposition, hypertension, diabetes, coronary artery disease, osteoporosis, muscle weakness and psychological disturbances. At experienced centers, initial surgical remission rate via transnasal, transphenoidal resection approaches 80% for tumors less than 1 cm, but may be as low as 30% for larger lesions and long–term recurrence in all groups approaches 25%. Residual disease may be managed with more radical surgery, pituitary–directed radiation, bilateral adrenalectomy, or medical therapy. This paper addresses current and novel therapies in various stages of development for Cushing’s disease.

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Biochemical Predictors of Outcome of Pituitary Surgery for Cushing's Disease
Neuroendocrinology, 11/12/09 Relevance Score: 78%

Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy
Journal of Clinical Endocrinology and Metabolism, 10/15/09 Relevance Score: 64%

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Endocrine Reviews, 11/11/09 Relevance Score: 62%

Regulation of Pituitary Function by Cytokines
Hormone Research, 10/27/09 Relevance Score: 46%

Role of the pituitary-bone axis in skeletal pathophysiology
Current Opinion in Endocrinology, Diabetes and Obesity, 11/03/09 Relevance Score: 45%