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The role of GNAS and other imprinted genes in the development of obesity
International Journal of Obesity, 11/02/09

Weinstein LS et al. – In this review the authors examine the role of imprinted genes in postnatal growth and metabolism, with an emphasis on the GNAS/Gnas locus. GNAS is a complex imprinted locus with multiple oppositely imprinted gene products, including the G–protein alpha–subunit Gsalpha that is expressed primarily from the maternal allele in some tissues and the Gsalpha isoform XLalphas that is expressed only from the paternal allele. Maternal, but not paternal, Gs mutations lead to obesity in Albright hereditary osteodystrophy. Mouse studies show that this phenomenon is due to Gsalpha imprinting in the central nervous system leading to a specific defect in the ability of central melanocortins to stimulate sympathetic nervous system activity and energy expenditure. In contrast mutation of paternally expressed XLalphas leads to opposite metabolic effects in mice. Although these findings conform to the 'kinship' model, the effects of other imprinted genes on body weight regulation do not conform to this model.

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Circulating and Adipose Tissue Gene Expression of Zinc-alpha2-Glycoprotein in Obesity: Its Relationship with Adipokine and Lipolytic Gene Markers in Subcutaneous and Visceral Fat
Journal of Clinical Endocrinology and Metabolism, 11/06/09 Relevance Score: 69%

Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study
Obesity, 11/17/09 Relevance Score: 67%

IPO8 and FBXL10: New Reference Genes for Gene Expression Studies in Human Adipose Tissue
Obesity, 11/03/09 Relevance Score: 67%

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome
American Journal of Clinical Nutrition, 10/21/09 Relevance Score: 67%

Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene–obesity interaction
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 10/19/09 Relevance Score: 67%