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Nishiyama KK et al. – Increases in cortical porosity (Ct.Po) and decreases in cortical thickness (Ct.Th) are associated with increased bone fragility. The purpose of this study was to validate an auto–segmentation method for high–resolution peripheral quantitative computed tomography (HR–pQCT) scans. The method offers promise as a valuable tool to measure Ct.Po and Ct.Th in vivo and investigate associations between cortical bone structure, age and disease status.

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