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Low Muscle Glycogen and Elevated Plasma FFA Modify but does not Prevent Exercise-induced PDH Activation in Human Skeletal Muscle
Diabetes, 10/28/09
Kiilerich K et al. – Muscle glycogen and plasma FFA attenuate exercise–induced PDH regulation in human skeletal muscle in a non–additive manner. This might be through regulation of PDK4 expression. The activation of PDH by exercise independent of changes in muscle glycogen or plasma FFA suggests that exercise overrules FFA–mediated inhibition of PDH (i.e. carbohydrate oxidation), and this may thus be one mechanism behind health promoting effects of exercise.
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