Endocrinology Medical News about FTO mutations

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

3. Rapid correction of low vitamin D status in nursing home residents

4. 2008 Exclusive Survey—Earnings: Good news for primary care income

5. Medicare pay-for-reporting effort draws fire from frustrated doctors

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Prevalence of loss of function FTO mutations in lean and obese individuals
Diabetes, 10/22/09

Meyre D et al. – Heterozygous, loss–of–function mutations in FTO exist but are found in both lean and obese subjects. While intron 1 SNPs are unequivocally associated with obesity in multiple populations and murine studies strongly suggest that FTO has a role in energy balance, it appears that loss of one functional copy of FTO in humans is compatible with being either lean or obese. Functional analyses of FTO mutations have given novel insights into structure–function relationships in this enzyme.

<< Previous
Effect of the urotensin-II receptor antagonist palosuran on...

Next >>
Medical treatment of Cushing's disease: Overview and recent...

Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
The Journal of Pathology, 10/16/09 Relevance Score: 48%

Genetic Testing for Long-QT Syndrome. Distinguishing Pathogenic Mutations From Benign Variants
Circulation, 10/23/09 Relevance Score: 47%

Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09 Relevance Score: 46%

MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09 Relevance Score: 46%

Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer
Cancer Epidemiology, Biomarkers & Prevention, 10/05/09 Relevance Score: 46%