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Hobbs RF et al. – Retrospective analyses, the 3D–RD calculations were expanded to include additional tumor dose estimates, and the conventional methodologies were reexamined to reveal the causes of the differences observed. A higher recommended administered activity than by an S–value–based method with a favorable clinical outcome was obtained. This approach permitted more aggressive treatment while adhering to patient–specific lung toxicity constraints. A retrospective analysis of the conventional methodologies with appropriate corrections yielded absorbed dose estimates consistent with 3D–RD.

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