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E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary Tumors
Molecular Endocrinology, 11/02/09
Zhou C et al. – These results elucidate a mechanism for abundant tumor hPTTG1 expression, whereby Rb inactivation releases E2F1 to induce hPTTG1. This signaling pathway may underlie the requirement of PTTG1 for pituitary tumorigenesis.
Shlomo Melmed, 11/03/09
| E2F1 and PTTG1 are concordantly overexpressed in Rb+/- murine pituitary tissues and in human pituitary tumors. E2F1 binds to the hPTTG1 promoter, activates hPTTG1 transcription and induces expression. These results elucidate a mechanism for abundant tumor hPTTG1 expression, whereby Rb inactivation releases E2F1 to induce hPTTG1. This signaling pathway may underlie the requirement of PTTG1 for pituitary tumorigenesis. |
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