Your Messages Inbox (38) 
Your Unread Messages
See All
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease 3. Rapid correction of low vitamin D status in nursing home residents 4. 2008 Exclusive Survey—Earnings: Good news for primary care income 5. Medicare pay-for-reporting effort draws fire from frustrated doctors
Your Article Summary
Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis
Journal of Clinical Endocrinology and Metabolism, 10/21/09
Fowler PA et al. – Falling second–trimester fetal testosterone is probably due to declining maternal hCG because Leydig cell LH/hCG responsiveness remains constant. Although maternal cigarette smoking reduces fetal hCG, the ratio of inactive LHCGR isoforms is reduced and gonadotropin drive maintains testosterone production near control levels. The lower relative abundance of inactive isoforms compared with the adult testis reflects the importance of LHCGR.
Paul A. Fowler, 10/22/09
| What the article shows is subtle changes in the LH/hCG receptor in the fetal testis during the second trimester. These changes are altered when the mother continues to smoke cigarettes while pregnant. Taken together with the fact that the fetal testis turns out to be relatively insensitive to LH/hCG, it is surprising that fetal testosterone production is not significantly reduced by exposure in-utero to cigarette smoke chemicals. However, in some fetuses, maternal cigarette smoking may be causing sufficient alterations in the LH/hCG - receptor - testis - testosterone sequence to contribute to observed associations between maternal cigarette smoking and an increased probability of reduced fertility in the resulting men. |
Today in Fetal Development...keeping you current
Receive free subspecialty "5-minute updates" via email
Timing and Trajectories of Fetal Growth Related to Cognitive Development in Childhood
American Journal of Epidemiology, 11/05/09
Intrauterine Cannabis Exposure Affects Fetal Growth Trajectories: The Generation R Study
Journal of the American Academy of Child and Adolescent Psychiatry, 10/29/09
Perinatal Outcomes in Isolated Single Umbilical Artery
American Journal of Perinatology, 10/26/09
Today in Reproductive Endocrinology...keeping you current
Receive free subspecialty "5-minute updates" via email
Comparison of Simvastatin and Metformin in Treatment of Polycystic Ovary Syndrome: Prospective Randomized Trial
Journal of Clinical Endocrinology and Metabolism, 11/20/09
Timetable of effects of testosterone administration to hypogonadal men on variables of sex and mood
The Aging Male, 11/13/09
Safety and efficacy of testosterone gel in the treatment of male hypogonadism
Clinical Interventions in Aging, 10/12/09
Sponsor
Article Search
Sponsor