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See Latest ArticlesFamilial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway
Arteriosclerosis, Thrombosis, and Vascular Biology, 10/20/09
Van Himbergen TM et al. – The data indicate that both men and women with FCH have alterations in the cholesterol synthesis pathway, resulting in 51% higher levels of lathosterol (and additionally desmosterol in women). Plasma levels of the cholesterol precursor sterol squalene were only slightly increased (6%), suggesting enhanced conversion of squalene to lathosterol in this disorder.
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