Endocrinology Medical News about Pioglitazone Treatment

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Pioglitazone Treatment Enlarges Subcutaneous Adipocytes in Insulin-Resistant Patients
Journal of Clinical Endocrinology and Metabolism, 10/15/09

Koenen TB et al. – Obesity–related insulin resistance is associated with an increase in adipocyte size. Whether such TZD–dependent morphological changes occur in adipose tissue of insulin–resistant patients is unclear. In the human situation, treatment of insulin–resistant subjects with pioglitazone improves insulin sensitivity, whereas at the same time, sc adipocyte cell surface increases.

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