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The Blood-Brain Barrier Thyroxine Transporter Organic Anion-Transporting Polypeptide 1c1 Displays Atypical Transport Kinetics
Endocrinology, 10/14/09

Westholm DE et al. – Oatp1c1–dependent substrate transport is a complex process involving substrate interaction with multiple binding sites and competition for binding with a variety of other substrates. A thorough understanding of atypical Oatp1c1 transport processes and substrate–dependent inhibition will allow better prediction of endo– and xenobiotic interactions with the Oatp transporter.

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