Endocrinology Medical News about Protein Kinase C

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Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses
Endocrinology, 10/15/09

Thaler JP et al. – By activating the Toll–like receptor 4–nuclear factor–kappaB signal transduction pathway, the bacterial endotoxin lipopolysaccharide (LPS) induces anorexia, weight loss, fever, and other components of the sickness response. Although hypothalamic aPKC signaling is not required for food intake inhibition by insulin or leptin, it plays a key role in inflammatory anorexia and fever induced by LPS.

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Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions
Oncogene, 11/05/09 Relevance Score: 81%

Thromboxane receptor [alpha] mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells
Lung Cancer, 10/29/09 Relevance Score: 81%

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway
Molecular Pharmacology, 11/10/09 Relevance Score: 80%

Myoglobin Induces Vascular Cell Adhesion Molecule-1 Expression through c-Src Kinase-Activator Protein-1/Nuclear Factor-kB Pathways
Nephron: Experimental Nephrology, 11/03/09 Relevance Score: 80%

A novel inhibitor of Chlamydophila pneumoniae protein kinase D inhibits phosphorylation of CdsD and suppresses bacterial replication
BMC Microbiology, 10/21/09 Relevance Score: 80%