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Boni–Schnetzler M et al. – Activation of TLR2 in purified human beta–cells and islets stimulated the expression of proinflammatory factors, and IL–1RI activity increased the TLR2 response in human islets. The authors conclude that FFA and TLR stimulation induce proinflammatory factors in islets and that IL–1RI engagement results in signal amplification.


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