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BMI and Neuronal Integrity in Healthy, Cognitively Normal Elderly: A Proton Magnetic Resonance Spectroscopy Study
Obesity, 10/14/09

Gazdzinski S et al. – The results provide evidence that elevated BMI is associated with neuronal abnormalities mostly in frontal brain regions that subserve higher cognitive functions and impulse control. Future studies need to evaluate whether these metabolite abnormalities are involved in the development and maintenance of weight problems.

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Stefan Gazdzinski, 10/15/09

The prevalence of weight problems in the US and around the world increases despite billions of $$$ being spent on weight loss programs and products. In this paper, we have noted decreased levels of N-acetyl-aspartate (NAA, marker of neuronal integrity) as a function of increasing body mass index (BMI) in a group of 23 healthy elderly. Lower levels of NAA, a brain chemical found exclusively in neurons, are hallmark of neurodegenerative diseases, such as Alzheimer's disease or multiple sclerosis. However, we did not find the association between elevated BMI and lower levels of NAA throughout the brain, but in anterior cingulate cortex- part of the reward system that is involved in impulse control. Thus, compromised neuronal integrity in brain region associated with impulse control may underlie the low success rates of efforts to loose weight and maintain it.

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