Endocrinology Medical News about Diabetes Mellitus Diabetes Mellitus, Type 2

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Attenuated Purinergic Receptor Function in Patients with Type 2 Diabetes
Diabetes, 10/28/09

Thaning P et al. – The vasodilatatory effect of the purinergic system is severely reduced in type 2 diabetic patients. The potency of nucleotides varies with the following rank order: UTP>ATP>>>ADO. This is not due to alterations in receptor distribution and mRNA expression, but may be due to differences in receptor sensitivity.

Exclusive Author Commentary
Pia Thaning, 11/11/09

The attenuation in purinergic receptor responses could, in part, be implicated in capillary rarefaction and impaired regulation of capillary recruitment in skeletal muscle tissue, known to compromise insulin sensitivity and glucose uptake. The current findings, in combination with existing evidence, provide a basis for further studies addressing the mechanisms underlying the reduced vascular function and exercise capacity in diabetic patients.

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Sodium Glucose Cotransporter 2 Inhibitors as a New Treatment for Diabetes Mellitus
Journal of Clinical Endocrinology and Metabolism, 11/10/09 Relevance Score: 97%

Evidence for an association with type 2 diabetes mellitus at the PPARG locus in a South Indian population
Metabolism-Clinical and Experimental, 11/03/09 Relevance Score: 97%

A Simulation of the Comparative Long-term Effectiveness of Liraglutide and Glimepiride Monotherapies in Patients with Type 2 Diabetes Mellitus
Pharmacotherapy, 10/28/09 Relevance Score: 97%

Hepatic fat and inflammation in type 2 diabetes mellitus
Metabolism-Clinical and Experimental, 10/26/09 Relevance Score: 97%

Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study
International Journal of Obesity, 10/16/09 Relevance Score: 97%