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Structural and electrophysiological changes in atherosclerotic radial artery grafts account for impairment of vessel reactivity
Atherosclerosis, 10/12/09

Mueed I et al. – The results show that vasocontractile properties of both mildly and severely atherosclerotic arteries are reduced when compared to normal RAs. A possible explanation for this could be decreased vascular compliance due to arterial stiffening and a substantial augmentation of K+ currents in sclerotic smooth muscle cells. The authors conclude that caution should be exercised when using RA grafts with atherosclerotic lesions since they could significantly impact the clinical outcome of CABG surgery.

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