Endocrinology Medical News about hypoglycemia

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Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia
Human Mutation, 09/30/09

Osbak KK et al. – The majority of activating mutations cluster in a discrete region of the protein termed the allosteric activator site. The identification of a GCK mutation in patients with both hyper– and hypoglycemia has implications for the clinical course and clinical management of their disorder.

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