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See Latest ArticlesA Novel Isoform of Human LZIP Negatively Regulates the Transactivation of the Glucocorticoid Receptor
Molecular Endocrinology, 09/25/09
Kang H et al. – The human leucine zipper protein (LZIP) is a basic leucine zipper transcription factor that is involved in leukocyte migration, tumor suppression, and endoplasmic reticulum stress–associated protein degradation. Although evidence suggests a diversity of roles for LZIP, its function is not fully understood, and the subcellular localization of LZIP is still controversial. The findings suggest that sLZIP functions as a negative regulator in glucocorticoid–induced transcriptional activation of GR by recruitment and activation of HDACs.
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