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Mechanisms to conserve glucose in lactating women during a 42-h fast
Endocrinology and Metabolism, 09/25/09
Mohammad MA et al. – Lactating women are at risk for hypoglycemia if fasting is extended beyond 30 h. The extra glucose demands of extended fasting during lactation appear to be compensated by increasing gluconeogenesis associated with ketosis, decreasing carbohydrate oxidation, and increasing protein and FFA oxidations.
M. W. Haymond, 09/28/09
| These studies represent one of an ongoing series of investigations into the maternal metabolic adaptation to lactation. From these and our previous studies, we established that healthy lactating women can safely fast for 24 hours without impacting milk production. In addition, the increased utilization of glucose in the women provides a unique model to explore the regulatory mechanisms involved in the adaptation to fasting and protection from hypoglycemia as well as the mechanism(s) for preservation of milk prodcution. |
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