Endocrinology Medical News about Monocarboxylate Transporter

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Evidence for a Homodimeric Structure of Human Monocarboxylate Transporter 8
Endocrinology, 10/01/09

Visser WE et al. – The human monocarboxylate transporter 8 (hMCT8) protein mediates transport of thyroid hormone across the plasma membrane. Association of hMCT8 mutations with severe psychomotor retardation and disturbed thyroid hormone levels has established its physiological relevance, but little is still known about the basic properties of hMCT8. The findings indicate that individual Cys residues are not important for the function of hMCT8 or suggest that hMCT8 has other yet–undiscovered functions in which cysteines play an essential role.

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ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer
Journal of Leukocyte Biology, 11/12/09 Relevance Score: 43%

Interindividual variability of drug transporters: Impact on opioid treatment in chronic renal failure
European Journal of Pain, 11/12/09 Relevance Score: 43%

Putative Transmembrane Domain 12 of the Human Organic Anion Transporter hOAT1 Determines Transporter Stability and Maturation Efficiency
Journal of Pharmacology and Experimental Therapeutics, 11/12/09 Relevance Score: 43%

The Blood-Brain Barrier Thyroxine Transporter Organic Anion-Transporting Polypeptide 1c1 Displays Atypical Transport Kinetics
Endocrinology, 10/14/09 Relevance Score: 43%

Transplacental pharmacokinetics of glyburide, rhodamine 123 and BODIPY FL prazosin; effect of drug efflux transporters and lipid solubility
Journal of Pharmacology and Experimental Therapeutics, 10/08/09 Relevance Score: 43%