Endocrinology

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Measurement uncertainty of 25-OH vitamin D determination with different commercially available kits: impact on the clinical cut offs
Osteoporosis International, 09/22/09

Cavalier E et al. – Due to “measurement uncertainty”, the “true” 25-OH vitamin D (25(OH)D) of a patient (whatever the commercially available assay tested) will be >80 nmol/L if its measured concentration is >100 nmol/L; thus, if a physician considers that a normal VTD status is a 25(OH)D level ?80 nmol/L, he should ensure that the patient’s results are ?100 nmol/L. Whatever the assay, the “true” 25(OH)D of a patient will be >80 nmol/L if its measured concentration is >100 nmol/L.

• We constituted three pools of serum with different 25(OH)D concentrations
• Each pool was assayed in triplicate during 5 days with the DiaSorin RIA, Liaison, Elecsys, and Chromsystems-HPLC assays

• We report a relatively high “measurement uncertainty” for the measurement of 25(OH)D for the four different techniques: the mean relative uncertainties, all techniques confounded were 19.4%, 16.0%, and 11.3% for pool 1 (35.3 nmol/L), pool 2 (79.5 nmol/L), and pool 3 (126.1 nmol/L), respectively

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