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Local lipopolysaccharide injection: A potential novel treatment for heterotopic ossification
Medical Hypotheses, 09/17/09
Xue DT et al. - Cell and molecular biology studies further found that LPS initiated the osteoclast formation, stimulated osteoclast activity and inhibited osteoblast differentiation. Given HO is an abnormality in bone modeling which increases bone mass within extraskeletal soft tissues, the authors herein hypothesize that local LPS injection might be a potential novel treatment for HO.
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