Endocrinology Medical News about Carney Complex

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Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGFbeta-Stimulated Apoptosis in Adrenocortical Cells
Cancer Research, 09/17/09

Ragazzon B et al. – PRKAR1A silencing decreased the percentage of apoptotic cells and the cleavage of apoptosis mediators [caspase–3, poly(ADP–ribose) polymerase, and lamin A/C]. Inactivating mutations of PRKAR1A observed in adrenocortical tumors alter SMAD3, leading to resistance to TGFbeta–induced apoptosis. This cross–talk between the PKA and the TGFbeta signaling pathways reveals a new mechanism of endocrine tumorigenesis.

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