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See Latest ArticlesCost effectiveness and screening interval of lipid screening in Hodgkins lymphoma survivors
Journal of Clinical Oncology, 09/17/09
Chen AB et al. – Lipid screening in survivors of HL, with statin therapy for screen-positive patients, improves survival and is cost effective. A screening interval of 3 years seems reasonable in the long-term follow-up of survivors of HL.
Methods- Decision-analytic model
- Evaluated lipid screening in a hypothetical cohort of 30-year-old survivors of HL
- Survived 5 years after mediastinal irradiation.
- Compared following strategies: no screening, and screening at 1-, 3-, 5-, or 7-year intervals
- Screen-positive patients treated with statins
- Costs estimated from Medicare fee schedules and medical literature. Sensitivity analyses performed
- Using an incremental cost-effectiveness ratio (ICER) threshold of $100,000 per quality-adjusted life-year (QALY) saved, lipid screening at every interval was cost effective relative to strategy of no screening
- 3-year interval cost effective relative to a 5-year interval
- Annual screening, relative to screening every 3 years, had an ICER of more than $100,000/QALY saved
- Factors with most influence on results included risk of cardiac events/death after HL, efficacy of statins in reducing cardiac events/death, and costs of statins
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