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Poulter NR et al. – There was no evidence that the superiority of amlodipine–based over atenolol–based therapy for patients with hypertension uncomplicated by coronary heart disease was attenuated with higher baseline heart rate. These data suggest that, in similar hypertensive populations without previous or current coronary artery disease, higher baseline heart rate is not an indication for preferential use of beta–blocker–based therapy.

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