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Carbohydrate complexity and proportion of serum FSH isoforms reflect pituitaryovarian activity in perimenopausal women and depot medroxyprogesterone acetate users
Clinical Endocrinology, 09/15/09
Loreti N et al. – FSH is synthesized and secreted in multiple glycosylation variants with different oligosaccharide structures; the endocrine milieu regulates the composition of FSH carbohydrate moiety. Serum FSH glycoforms with increased sialylation and decreased oligosaccharide complexity reflect the decline of the gonadal activity induced either by age or by the use of a DMPA as a contraceptive.
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