Endocrinology Medical News about PTEN

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Pathological Effects of Prostate Cancer Correlate With Neuroendocrine Differentiation and PTEN Expression After Bicalutamide Monotherapy
The Journal of Urology, 09/17/09

Ham WS et al. – PTEN inactivation and neuroendocrine differentiation were related to refractoriness to bicalutamide therapy. These results support the hypothesis that neuroendocrine differentiation is caused by activation of the serine threonine kinase Akt pathway, which results from PTEN inactivation.

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UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
Oncogene, 11/05/09 Relevance Score: 90%

Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial Cells
Cancer Research, 11/02/09 Relevance Score: 89%

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
Journal of Experimental Medicine, 11/06/09 Relevance Score: 88%

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1
Human Molecular Genetics, 11/03/09 Relevance Score: 87%

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme
Cancer Research, 10/20/09 Relevance Score: 87%