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Activity of Human Pregnancy Insulin-Like Growth Factor Binding Protein-3: Determination by Reconstituting Recombinant Complexes
Endocrinology, 09/09/09
Yan X et al. – It is proposed that proteolysis of IGFBP–3 into two discrete complementary fragments does not significantly increase IGF bioavailability, consistent with previous findings that proteolyzed IGFBP–3 in pregnancy serum is functionally normal and circulates as part of the IGF ternary complexes.
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