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See Latest ArticlesActivation of a prometastatic gene expression program in hypoxic neuroblastoma cells
Endocrine-Related Cancer, 08/28/09
Russo VC et al. – NB cell adaptation to hypoxia, in addition to the modulation of HIF1alpha and VEGF expression and nuclear translocation of ID1 and ID2 transcription factors, involve in the activation of a gene expression program consistent with the pro–metastatic events. These processes are probably responsible for the NB cell transition from an adherent phenotype to a highly migratory, invasive and aggressive NB cell type.
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