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Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells
Endocrine-Related Cancer, 08/26/09
Hyder SM et al. – Conditioned medium from progestin–treated breast cancer cells stimulates endothelial cell proliferation in the absence though not in the presence of antibody to TSP–1, indicating that TSP–1 secreted by breast cancer cells could be pro–angiogenic. Since tumor cell–derived TSP–1 has the potential to promote angiogenesis in the tumor microenvironment, it could be a potential target for breast cancer therapy.
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