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See Latest ArticlesDifferential articular calcified cartilage and subchondral bone in postmenopausal women with osteoarthritis and osteoporosis: Two-dimensional analysis
Joint, Bone, Spine, 08/24/09
Zhang ZM et al. – Study demonstrates that the pathogenesis of osteoarthritis (OA) and osteoporosis (OP) were influenced by differential properties of articular calcified cartilage (ACC) and subchondral bone microstructure. Structural properties of the subchondral mineralized tissue supported that an inverse relationship existed between postmenopausal women with OA and OP.
Methods- A comparison of the structural properties of ACC and subchondral bone between postmenopausal women with OA and OP
- 8 femoral heads taken from postmenopausal women during total hip replacement surgery due to primary OA
- They were compared with 9 femoral heads obtained from age-matched women with OP during hemi-hip arthroplasty surgery due to osteoporotic fracture
- 2D histomorphometric sections were prepared to measure the thickness of ACC and bone histomorphometric parameters
- Ratio of ACC to the total articular cartilage (TAC) was also calculated in all bone specimens
- Osteoarthritic donors had higher ACC and the ratio of ACC to TAC
- Lower bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N) and the ratio of nodes to termini (Nd/Tm) were demonstrated in donors with OP
- However, trabecular space (Tb.Sp) increased in these osteoporotic pts
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