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See Latest ArticlesRelationship between historical height loss and vertebral fractures in postmenopausal women
Clinical Rheumatology, 08/21/09
Bennani L et al. – Data demonstrate significant positive associations between historical height loss (HHL), vertebral fractures (VF), number of VF, and grade of VF. However, this relationship is not clinically pertinent; HHL cannot be used as a reliable clinical test for detecting VF in postmenopausal Moroccan women.
Methods- Main objectives of this study were to:
- Evaluate the relationship between HHL and prevalent VF in postmenopausal Moroccan women, and
- Estimate its accuracy as a clinical test for detecting VF
- 288 postmenopausal women; all subjects had bone density measurements and spinal radiographs
- Vertebral bodies (T4–L4) were graded using the semi-quantitative method of Genant
- HHL was calculated as the difference between a pt’s tallest recalled height and the current measured height
- Mean age was 58.4±7.8 yrs; 31% of pts were osteoporotic, and 46.5% had VF
- Patients with VF had lost more height than those w/o VF
- Univariate analysis: HHL was positively correlated to both number and grade of prevalent VF
- The area under the receiver operating characteristics curve for the ability of HHL to detect VF was 0.60
- HHL threshold for detecting VF was >1.5 cm, its sensitivity was 58%, and its specificity was 61%
- The positive predictive value was 53%, and the negative predictive value was 65%
- With HHL >1.5 cm, positive likelihood ratio was 1.49 with 95% CI, 1.07, 2.06
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