Endocrinology Medical News about Ankylosing spondylitis, Osteoporosis, Vitamin D

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The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis
Rheumatology International, 08/21/09

Baskan BM et al. – Data suggest that vitamin D deficiency in ankylosing spondylitis (AS) may indirectly lead to osteoporosis by causing an increase in the inflammatory activity; it would be beneficial to monitorize vitamin D levels together with bone mineral density (BMD) measurements in order to determine the patients under osteoporosis risk.

Methods

An investigation of the relation between osteoporosis and vit D and the disease activity in pts with AS
In 100 AS pts and 58 healthy individuals:
- Routine blood and urine tests
- Serum 25-(OH)D3, parathormone (PTH), CRP, ESR
- Total calcium, ionized calcium, and phosphorous levels
  were measured
BMD measurements were performed at the anterior–posterior and lateral lumbar and femur regions
Anterior–posterior and lateral thoracic and lumbosacral radiography was performed on all participants
The disease activity was evaluated by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)
Functional status by Bath Ankylosing Spondylitis Functional Index (BASFI)
Mobility by Bath Ankylosing Spondylitis Metrology Index (BASMI)

Results

In the patient group, BMD values obtained from the lateral lumbar and femur regions and serum vit D levels were lower than control group
A negative relation was determined between the lateral lumbar BMD values and ESR, CRP, and BASDAI scores of pts with AS
The ESR, CRP levels, and BASMI scores of the AS pts with osteoporosis were higher, vs pts w/o osteoporosis
The negative correlation between serum 25-(OH)D3 level and ESR, CRP levels did not reach a significant level in pts with AS
The positive correlation between PTH levels and ESR, and the negative correlation between CRP and BASDAI also did not reach a significant level

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