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Metformin reverses the deleterious effects of high glucose on osteoblast function
Journal of Diabetes and its Complications, 08/14/09
Zhen D et al. – The findings suggest that the dual effects of glucose on cell proliferation and development are dose dependent. Metformin not only significantly decreased intracellular ROS and apoptosis, but also had a direct osteogenic effect on osteoblasts at all glucose concentrations, which could be partially mediated via promotion of Runx2 and IGF–1 expression.
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