Endocrinology Medical News about hypoparathyroidism

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Successful treatment of postsurgical hypoparathyroidism by intramuscular injection of vitamin D3 in a patient associated with malabsorption syndrome due to multiple abdominal surgeries
Journal of Bone and Mineral Metabolism, 08/10/09

Sato K et al. – The data suggest that intramuscular injection of 300,000 IU vitamin D3 at an interval of a few months to maintain a slightly increased serum level of 25(OH)D and a slightly decreased serum level of calcium is a safe and cost–effective treatment in such a parathyroid hormone–deficient hypoparathyroid patient with malabsorption syndrome.

Exclusive Author Commentary
Kanji Sato, 08/17/09

The patient was suffering from protracted hypocalcemia (tetany) requiring self-injection of calcium gluconate because of PTH-deficient (post-surgical hypoparathyroidism) and malabsorption syndrome, leading to particulary severe malabsorption of active vitamin D3 (1a-OHD3 or 1,25(OH)2D3. By parenteral administarion of vitamin D3, serum levels of 25-OHD and calcium were maintained at the supranormal level (60-80ng/ml) and slightly below the normal level (7-8mg/dl), respectively. The patient has been symtom-free for the last one and half years. The appropriate dose of vitamin D3 is 300,000 U im at ever 2-3 months in the winter season and 3-4 months in the summer season.

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