Endocrinology Medical News about neuropathic pain; glucocorticoid; NMDA receptor

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Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation
Brain, Behavior, and Immunity, 07/31/09

Alexander JK et al. – There is growing recognition that psychological stress influences pain...These data suggest that the hormonal responses elicited by stress exacerbate neuropathic pain through enhanced central sensitization. Moreover, drugs that inhibit glucocorticoids (GCs) and/or NMDAR signaling could ameliorate pain syndromes caused by stress.

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Neuropathic pain: Peripheral and central mechanisms
European Journal of Pain, 11/12/09 Relevance Score: 70%

Targeting the NMDA Receptor Subunit NR2B for the Treatment of Neuropathic Pain
Neurotherapeutics, 10/05/09 Relevance Score: 70%

The pharmacological treatment of neuropathic pain
European Journal of Pain, 11/12/09 Relevance Score: 69%

Characterization of chronic pain patients in German pain centers. Core data from more than 10,000 patients
Schmerz, 10/06/09 Relevance Score: 69%

Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Neurotherapeutics, 10/05/09 Relevance Score: 69%