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C-reactive protein among community-dwelling hypertensives on single-agent antihypertensive treatment
Journal of the American Society of Hypertension, 07/30/09

Fulop T et al. – Antihypertensive medication class may influence inflammation, particularly in pts on renin-angiotensin-aldosterone system (RAAS) inhibitors.

• Cross-sectional study of C-reactive protein (CRP) levels on primary hypertensive pts on single-agent antihypertensive therapy
• Pts from community-based biracial Genetic Epidemiology Network of Arteriopathy cohort
• Linear regression models to assess association of antihypertensive medication class with log-transformed CRP after adjustment
• Adjustments for age, gender, ethnicity, body mass index, smoking, diabetes, hydroxymethylglutaryl CoA reductase inhibitor use, achieved blood pressure control (<140/90 mm Hg), serum creatinine, and urine albumin-to-creatinine ratios

• Single-agent therapy for hypertension for 662 pts in cohort
• Median CRP levels differed across pts: 0.40 mg/dL for pts on diuretics, 0.34 mg/dL on calcium-channel blockers, 0.25 mg/dL on beta-blockers and 0.27mg/dL on RAAS inhibitors
• On multivariable adjustment, group on RAAS inhibitors had 20% lower mean CRP on average vs group on diuretics
• Differences between other medication classes not apparent
• Heart rate had strong association with CRP

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