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Effects of Initial Therapy for Five Years with Somatostatin Analogs for Acromegaly on Growth Hormone and Insulin-like Growth Factor-I Levels, Tumor Shrinkage, and Cardiovascular disease: A Prospective Study
Journal of Clinical Endocrinology and Metabolism, 07/22/09
Colao A et al. – In patients with severe co–morbidities and in those who refuse surgery, 5 yrs of exclusive SSA therapy induce successful control of GH and IGF–I, tumor shrinkage (by median 80%) and improvement of hypertension, cardiac performance and dyslipidemia. No patient was withdrawn from treatment because of side effects and glucose tolerance was stable.
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