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Parathyroid Hormone-Related Protein Regulates Cell Survival Pathways via Integrin alpha6 beta4-Mediated Activation of Phosphatidylinositol 3-Kinase/Akt Signaling
Molecular Cancer Research, 07/13/09
Bhatia V et al. - The observations provide evidence of a link between PTHrP and the PI3K/Akt signaling pathway through integrin alpha6 beta4, resulting in the activation of survival pathways. Targeting PTHrP production in prostate cancer may thus prove therapeutically beneficial.
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