Endocrinology

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Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors
Virchows Archiv, 07/06/09

Szabo PM et al. – Data suggest that adrenocortical tumorigenesis might be characterized by reduced histamine biosynthesis; furthermore, different adrenocortical tumor subtypes may show unique histamine receptor expression profiles.

• An investigation of the involvement of histamine in human adrenocortical tumorigenesis
• Expression of genes and proteins involved in:
  • Biosynthesis (histidine decarboxylase, HDC)
  • Action (histamine receptors: HRH1–HRH4), and
  • Metabolism
    of histamine was examined in the normal human adrenal cortex and in adrenocortical tumors
• 15 normal adrenals and 43 tumors were studied
• mRNA expression was examined by RT-PCR
• Western-blotting and IHC were used for the study of proteins
• Tissue histamine content was determined by ELISA

• All proteins involved in histamine biosynthesis and action were present both in the normal adrenal cortex and in the tumors studied
• HDC expression and histamine content was highest in the normal tissues and lower in benign tumors
• Whereas it was significantly less in adrenocortical cancer (ACCs)
• HRH3 expression was higher in ACC samples than in the other groups

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