Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease 3. Rapid correction of low vitamin D status in nursing home residents 4. 2008 Exclusive Survey—Earnings: Good news for primary care income 5. Medicare pay-for-reporting effort draws fire from frustrated doctors
Your Article Summary
See Latest ArticlesMetformin inhibits aromatase via an ERK (extracellular signal-regulated kinase) - mediated pathway
Endocrinology, 07/07/09
Rice S et al. - The authors have shown for the first time in human granulosa cells that metformin significantly attenuated basal and insulin stimulated P450 aromatase mRNA expression and activity, via silencing of key promoters. This occurred by activation of MEK/ERK pathway which negatively regulates aromatase production. This is an important consideration given metformin's widespread use in PCOS and may further support a possible therapeutic indication in oestrogendependent breast tumours.
Related Articles
The expression of p53, bcl-2, bax, fas and fasL in the primary tumour and lymph node metastases of breast cancer
Acta Oncologica, 11/02/09
Relevance Score: 70%
Biological role of NHERF1 protein expression in breast cancer
Histopathology, 11/12/09
Relevance Score: 68%
Assessment of breast cancer opportunistic screening by clinical-pathological indicators: A population-based study
British Journal of Cancer, 10/30/09
Relevance Score: 68%
The prognostic significance of single hormone receptor positive metastatic breast cancer: An analysis of three randomised phase III trials of aromatase inhibitors
The Breast, 10/21/09
Relevance Score: 67%
Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers
BMC Cancer, 10/14/09
Relevance Score: 67%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer
Carcinogenesis, 12/15/09
HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress
Carcinogenesis, 12/15/09
Gene expression of PPARgamma and PGC-1alpha in human omental and subcutaneousadipose tissue is related to insulin resistance markers and mediates beneficial effects of physical training
European Journal of Endocrinology, 12/15/09
Today in Pharmacology/kinetics...keeping you current
Receive free subspecialty "5-minute updates" via email
The role of flow-mediated dilatation in the evaluation and development of antiatherosclerotic drugs
Current Opinion in Lipidology, 12/15/09
Thiazolidinediones and the liver in humans
Current Opinion in Lipidology, 12/15/09
Effect of Obesity on Platelet Reactivity and Response to Low-Dose Aspirin
Preventive Cardiology, 12/15/09
Today in Reproductive Endocrinology...keeping you current
Receive free subspecialty "5-minute updates" via email
Defining hyperandrogenism in polycystic ovary syndrome: measurement of testosterone and androstenedione by liquid chromatography-tandem mass spectrometry and analysis by receiver operator characteristic (ROC) plots
European Journal of Endocrinology, 12/15/09
A new FSHbeta mutation in a 29 year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH
European Journal of Endocrinology, 12/15/09
Hypogonadism in females with Prader-Willi syndrome from infancy to adulthood: variable combinations of a primary gonadal defect and hypothalamic dysfunction
European Journal of Endocrinology, 12/15/09
Sponsor
Article Search
Sponsor
Sponsor