Endocrinology Medical News about TURNER SYNDROME

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X-chromosome gene dosage and the risk of diabetes in turner syndrome
Journal of Clinical Endocrinology and Metabolism, 07/01/09

Bakalov VK et al. - Type-2 DM associated with deficient insulin release is significantly increased among women with monosomy for the X chromosome, but is even more greatly increased among women with monosomy for Xp coupled with trisomy for Xq. These data suggest that haploinsufficiency for unknown Xp genes increases risk for DM and that excess dosage of Xq genes compounds the risk.

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