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Jnk1/2 activation by tnf- induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by lxr agonists
Journal of Clinical Endocrinology and Metabolism, 07/01/09
Fernandez-Veledo S et al. - TNF-alpha induces insulin resistance on glucose uptake in human visceral but not in subcutaneous adipocytes, suggesting depot-specific effects of TNF-alpha on glucose uptake. Activation of JNK1/2 appears to be involved in serine phosphorylation of IRS1 and subsequently insulin resistance on glucose uptake, a state that can be reversed by LXR agonists.
Today in Basic Science/Genetics...keeping you current
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Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies
European Journal of Endocrinology, 11/05/09
PTH and IL21R May Underlie Variation of Femoral Neck Bone Mineral Density as Revealed by a Genome-Wide Association Study
Journal of Bone and Mineral Research, 11/03/09
Bone signaling pathways and treatment of osteoporosis
Expert Review of Endocrinology & Metabolism, 11/10/09
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Carbohydrate-restricted diets for obesity and related diseases: An update
Current Atherosclerosis Reports, 11/17/09
Effects of Walnut Consumption on Endothelial Function in Type 2 Diabetics: A Randomized, Controlled, Cross-Over Trial
Diabetes Care, 11/04/09
Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes
Journal of Clinical Endocrinology and Metabolism, 11/10/09
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Carbohydrate-restricted diets for obesity and related diseases: An update
Current Atherosclerosis Reports, 11/17/09
Exercise and diet in weight management: updating what works
British Journal of Sports Medicine, 11/11/09
Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality
European Heart Journal, 11/24/09
Today in Pharmacology/kinetics...keeping you current
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Bisphosphonate therapy: When not to monitor BMD
The Journal of Family Practice, 11/02/09
Comparison of Simvastatin and Metformin in Treatment of Polycystic Ovary Syndrome: Prospective Randomized Trial
Journal of Clinical Endocrinology and Metabolism, 11/20/09
Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes
Journal of Clinical Endocrinology and Metabolism, 11/10/09
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