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Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes
Circulation, 07/02/09

Tchaikovski V et al. - The elevated advanced glycation end products expression and increased oxidative stress in diabetic monocytes lead to activation of VEGFR-1–related signaling pathways and to desensitization of VEGFR-1 responses. These data establish VEGF resistance as a novel molecular concept for DM-related cellular dysfunction.

Exclusive Author Commentary
Johannes Waltenberger, 07/02/09

This article highlights the molecular mechanismas that lead to cellular dysfunction in diabetes mellitus. They can be explained by the novel concept of VEGF resistance. Please read the clinical perspective article at the end of the publication on page 159! This is all you should know and memorize!

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