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Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes
Circulation, 07/02/09
Tchaikovski V et al. - The elevated advanced glycation end products expression and increased oxidative stress in diabetic monocytes lead to activation of VEGFR-1–related signaling pathways and to desensitization of VEGFR-1 responses. These data establish VEGF resistance as a novel molecular concept for DM-related cellular dysfunction.
Johannes Waltenberger, 07/02/09
| This article highlights the molecular mechanismas that lead to cellular dysfunction in diabetes mellitus. They can be explained by the novel concept of VEGF resistance. Please read the clinical perspective article at the end of the publication on page 159! This is all you should know and memorize! |
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American Journal of Clinical Nutrition, 12/10/09
Today in Diabetes...keeping you current
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Risk Factors for Failure of Transmetatarsal Amputation in Diabetic Patients: A Cohort Study
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The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with Chronic Kidney Disease: a randomised controlled trial
BMC Nephrology, 12/11/09
Nicotinamide overload may play a role in the development of type 2 diabetes
World Journal of Gastroenterology, 12/10/09
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