Your Article Summary
See Latest ArticlesMelperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics
Human Psychopharmacology: Clinical and Experimental, 06/29/09
Bobo WV et al. - Melperone did not significantly increase prolactin PRL levels in male patients. However, melperone and typical neuroleptics caused increase in PRL levels in females. Further study of melperone's effects on PRL concentration is warranted.
Methods- Analysis of pre- and post-treatment PRL levels collected prospectively per protocol in a non-randomized study of 26 melperone-, 76 clozapine-, and 66 neuroleptic-treated patients with schizophrenia or schizoaffective disorder.
- Cross-sectional analysis of a larger sample of patients with PRL data was also performed.
- For males, post-treatment PRL levels were significantly higher in the typical neuroleptic group compared with the melperone (p = 0.0001) and clozapine (p = 0.0001) groups, with no significant difference between clozapine and melperone.
- For females, post-treatment PRL levels were significantly higher in the melperone group as compared to the clozapine group (p = 0.004).
- There were too few typical neuroleptic-treated females to permit analysis of this sample.
- However, the cross-sectional analysis of PRL data confirmed the results for melperone- and clozapine-treated females, and showed higher PRL levels in typical neuroleptic-treated females as compared with those who received melperone and clozapine.
Related Articles
Antipsychotic-induced hyperprolactinaemia in patients with schizophrenia: considerations in relation to bone mineral density
Journal of Psychiatric and Mental Health Nursing, 11/09/09
Relevance Score: 66%
Aripiprazole versus other atypical antipsychotics for schizophrenia
Cochrane Reviews, 10/21/09
Relevance Score: 64%
First-generation antipsychotic long-acting injections v. oral antipsychotics in schizophrenia: systematic review of randomised controlled trials and observational studies
British Journal of Psychiatry, 11/12/09
Relevance Score: 44%
Cardiometabolic Risk of Second-Generation Antipsychotic Medications During First-Time Use in Children and Adolescents
JAMA, 10/29/09
Relevance Score: 43%
Antipsychotic effects on auditory sensory gating in schizophrenia patients
European Neuropsychopharmacology, 10/21/09
Relevance Score: 43%
Today in Pharmacology/kinetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Rosiglitazone was non-inferior to metformin plus sulphonylurea for CV events but increased risk of HF and fractures in type 2 diabetes
Evidence-Based Medicine, 12/07/09
In patients with type 2 diabetes, perindopril-indapamide had similar relative reductions in mortality and cardiac events regardless of AF status
Evidence-Based Medicine, 12/07/09
The association between thiazolidinediones and hospitalisation for fracture in type 2 diabetic patients: a Taiwanese population-based nested case-control study
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 12/04/09